SLCO1B1 - Solute carrier organic anion transporter family member 1B1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SLCO1B1 »  Solute carrier organic anion transporter family member 1B1
 
Protein also known as:  Sodium-independent organic anion-transporting polypeptide 2 (OATP-2).
Gene name:  SLCO1B1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 132 1
GENE REF ISO

Function

 show evidences
Overview 
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the organo anion transporter (oat) family  2.A.60.1.5  
GO molecular function 
Sodium-independent organic anion transmembrane transporter activitydefinition[GO:0015347]  
1
  • TASPINC
GO biological process 
Organic anion transportdefinition[GO:0015711]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+10599  
According to Reactome, this protein belongs to the following pathways:
Recycling of bile acids and salts  REACT_11042  
Transport of organic anions  REACT_23988  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLCO1B1
GenomeRNAi: 10599
PRO: PR:Q9Y6L6
Chemistry
GuidetoPHARMACOLOGY: 1220