SLCO1B1 - Solute carrier organic anion transporter family member 1B1 - human protein (Medical)
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SLCO1B1 »  Solute carrier organic anion transporter family member 1B1
Protein also known as:  Sodium-independent organic anion-transporting polypeptide 2 (OATP-2).
Gene name:  SLCO1B1
Entry whose protein(s) existence is based on evidence at protein level
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1 132 1

Displayed isoform: Iso 1



 show evidences
Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. The disease is caused by mutations affecting the gene represented in this entry.  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following diseases:
Atorvastatin toxicity  240851  
Pravastatin toxicity  240903  
Rosuvastatin toxicity  240909  
Rotor syndrome  3111  
Simvastatin toxicity  240913  
Susceptibility to adverse reaction due to atorvastatin treatment  240961  
Susceptibility to adverse reaction due to pravastatin treatment  240981  
Susceptibility to adverse reaction due to rosuvastatin treatment  240983  
Susceptibility to adverse reaction due to simvastatin treatment  240985  
Susceptibility to myopathies due to statin treatment  306566  
According to DrugBank, this protein binds/interacts with the following drugs:
Digoxin  DB00390  
Gemfibrozil  DB01241  
Pravastatin  DB00175  


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 10599
GeneReviews: SLCO1B1
MIM: 237450
PharmGKB: PA134865839
Polymorphism databases
DMDM: 12643959
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.