SLCO1B1 - Solute carrier organic anion transporter family member 1B1 - human protein (Medical)
 
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SLCO1B1 »  Solute carrier organic anion transporter family member 1B1
 
Protein also known as:  Sodium-independent organic anion-transporting polypeptide 2 (OATP-2).
Gene name:  SLCO1B1
Entry whose protein(s) existence is based on evidence at protein level
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1 138 1
GENE REF ISO

Displayed isoform: Iso 1

 
 

Medical

 show evidences
Disease 
Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. The disease is caused by mutations affecting the gene represented in this entry.  
2
  • UniProtKB
According to Orphanet, this protein is involved in the following diseases:
Atorvastatin toxicity  240851  
Pravastatin toxicity  240903  
Rosuvastatin toxicity  240909  
Rotor syndrome  3111  
Simvastatin toxicity  240913  
Susceptibility to adverse reaction due to atorvastatin treatment  240961  
Susceptibility to adverse reaction due to pravastatin treatment  240981  
Susceptibility to adverse reaction due to rosuvastatin treatment  240983  
Susceptibility to adverse reaction due to simvastatin treatment  240985  
Susceptibility to myopathies due to statin treatment  306566  
Pharmaceutical 
According to DrugBank, this protein binds/interacts with the following drugs:
Acetylcysteine  DB06151  
Aminohippurate  DB00345  
Atorvastatin  DB01076  
Axitinib  DB06626  
Benzylpenicillin  DB01053  
Bezafibrate  DB01393  
Cabazitaxel  DB06772  
Caspofungin  DB00520  
Conjugated Estrogens  DB00286  
Cyclosporine  DB00091  
Dabrafenib  DB08912  
Dextrothyroxine  DB00509  
Digoxin  DB00390  
Dinoprostone  DB00917  
Eltrombopag  DB06210  
Estradiol  DB00783  
Estrone  DB00655  
Ezetimibe  DB00973  
Fexofenadine  DB00950  
Fluvastatin  DB01095  
Gadoxetate  DB08884  
Gemfibrozil  DB01241  
Indinavir  DB00224  
Irinotecan  DB00762  
L-Carnitine  DB00583  
Levothyroxine  DB00451  
Liothyronine  DB00279  
Liotrix  DB01583  
Lovastatin  DB00227  
Methotrexate  DB00563  
Mycophenolate mofetil  DB00688  
Nelfinavir  DB00220  
Olmesartan  DB00275  
Ouabain  DB01092  
Pantoprazole  DB00213  
Pazopanib  DB06589  
Penicillamine  DB00859  
Pioglitazone  DB01132  
Pitavastatin  DB08860  
Pravastatin  DB00175  
Quinidine  DB00908  
Repaglinide  DB00912  
Rifampicin  DB01045  
Rilpivirine  DB08864  
Ritonavir  DB00503  
Rosiglitazone  DB00412  
Rosuvastatin  DB01098  
Saquinavir  DB01232  
SIMEPREVIR  DB06290  
Simvastatin  DB00641  
Sirolimus  DB00877  
Sumatriptan  DB00669  
Valsartan  DB00177  
Verapamil  DB00661  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Organism-specific databases
CTD: 10599
GeneReviews: SLCO1B1
MIM: 237450
PharmGKB: PA134865839
Polymorphism databases
DMDM: 12643959
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.