CSNK1G3 - Casein kinase I isoform gamma-3 - human protein (Function)
 
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CSNK1G3 »  Casein kinase I isoform gamma-3   [ EC 2.7.11.1 ]  (CKI-gamma 3)
 
Gene name:  CSNK1G3
Entry whose protein(s) existence is based on evidence at protein level
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1 28 6
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hedgehog signaling pathway  hsa04340+1456  
Note 
Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1456
PRO: PR:Q9Y6M4
Chemistry
GuidetoPHARMACOLOGY: 2001