CAPN6 - Calpain-6 - human protein (Function)
 
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Protein
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CAPN6 »  Calpain-6
 
Protein also known as:  Calpain-like protease X-linked.
Gene name:  CAPN6
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198] silver  
  • IBARefGenome
Microtubule bindingdefinition[GO:0008017]  
  • ISSOrtholog Curator
GO biological process 
Microtubule bundle formationdefinition[GO:0001578]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
  • ISSOrtholog Curator
Enzymatic activity 
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 827
PRO: PR:Q9Y6Q1