NCOA3 - Nuclear receptor coactivator 3 - human protein (Function)
 
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NCOA3 »  Nuclear receptor coactivator 3   [ EC 2.3.1.48 ]  (NCoA-3)
 
Protein also known as:  Thyroid hormone receptor activator molecule 1 (TRAM-1).
Gene name:  NCOA3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.  
1
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • UniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • UniProtKB
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • UniProtKB
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • RefGenome
Nuclear hormone receptor bindingdefinition[GO:0035257]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Thyroid hormone receptor bindingdefinition[GO:0046966]  
1
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
4
  • UniProtKB
Transcription factor activity, RNA polymerase II transcription factor recruitingdefinition[GO:0001135] silver  
1
  • Ortholog Compara
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • UniProtKB
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • BHF-UCL
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • RefGenome
Histone acetylationdefinition[GO:0016573]  
3
  • GOC
  • InterPro 2 GO
  • EC 2 GO
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • RefGenome
Labyrinthine layer morphogenesisdefinition[GO:0060713] silver  
1
  • Ortholog Compara
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Negative regulation of stem cell differentiationdefinition[GO:2000737] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of keratinocyte differentiationdefinition[GO:0045618]  
2
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Receptor transactivationdefinition[GO:0035624]  
1
  • UniProtKB
Regulation of RNA biosynthetic processdefinition[GO:2001141]  
1
  • UniProtKB
Regulation of stem cell divisiondefinition[GO:2000035] silver  
1
  • Ortholog Compara
Regulation of stem cell population maintenancedefinition[GO:2000036] silver  
1
  • Ortholog Compara
Regulation of stem cell proliferationdefinition[GO:0072091] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
2
  • UniProtKB
It is regulated in the following manner
Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
MAPK6/MAPK4 signaling  R-HSA-5687128  
PPARA activates gene expression  R-HSA-1989781  
Transcriptional regulation of white adipocyte differentiation  R-HSA-381340  
Note 
NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links