MAP3K4 - Mitogen-activated protein kinase kinase kinase 4 - human protein (Function)
 
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MAP3K4 »  Mitogen-activated protein kinase kinase kinase 4   [ EC 2.7.11.25 ]
 
Protein also known as:  MAPK/ERK kinase kinase 4 (MEKK 4).
Gene name:  MAP3K4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • RefGenome
MAP kinase kinase kinase activitydefinition[GO:0004709]  
2
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • RefGenome
Activation of MAPKK activitydefinition[GO:0000186]  
2
  • UniProtKB
Chorionic trophoblast cell differentiationdefinition[GO:0060718] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • Ortholog Curator
Male germ-line sex determinationdefinition[GO:0019100] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165]  
4
  • GOC
  • RefGenome
  • EC 2 GO
Placenta developmentdefinition[GO:0001890] silver  
1
  • Ortholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • UniProtKB
Positive regulation of p38MAPK cascadedefinition[GO:1900745]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of gene expressiondefinition[GO:0010468] silver  
1
  • Ortholog Compara
Response to UV-Cdefinition[GO:0010225]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
GnRH signaling pathway  hsa04912+4216  
MAPK signaling pathway  hsa04010+4216  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K4
GenomeRNAi: 4216
PRO: PR:Q9Y6R4
Chemistry
GuidetoPHARMACOLOGY: 2079