WASF2 - Wiskott-Aldrich syndrome protein family member 2 - human protein (Function)
 
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WASF2 »  Wiskott-Aldrich syndrome protein family member 2  (WASP family protein member 2)
 
Protein also known as:  Verprolin homology domain-containing protein 2.
Gene name:  WASF2
Family name: SCAR/WAVE
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 70 2
GENE REF ISO

Function

 show evidences
Overview 
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
2
  • IMPUniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Actin filament-based movementdefinition[GO:0030048] silver  
  • IEAOrtholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Ameboidal cell migrationdefinition[GO:0001667] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Lamellipodium assemblydefinition[GO:0030032] silver  
  • IEAOrtholog Compara
Lamellipodium morphogenesisdefinition[GO:0072673] silver  
  • IEAOrtholog Compara
Megakaryocyte developmentdefinition[GO:0035855] silver  
  • IEAOrtholog Compara
Negative regulation of stress fiber assemblydefinition[GO:0051497]  
1
  • IMPUniProtKB
Positive regulation of lamellipodium assemblydefinition[GO:0010592]  
2
  • IMPUniProtKB
Rac protein signal transductiondefinition[GO:0016601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+10163  
Bacterial invasion of epithelial cells  hsa05100+10163  
Fc gamma R-mediated phagocytosis  hsa04666+10163  
Regulation of actin cytoskeleton  hsa04810+10163  
Salmonella infection  hsa05132+10163  
Shigellosis  hsa05131+10163  
According to Reactome, this protein belongs to the following pathway:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WASF2
GenomeRNAi: 10163
PRO: PR:Q9Y6W5