WASF2 - Wiskott-Aldrich syndrome protein family member 2 - human protein (Function)
 
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WASF2 »  Wiskott-Aldrich syndrome protein family member 2  (WASP family protein member 2)
 
Protein also known as:  Verprolin homology domain-containing protein 2.
Gene name:  WASF2
Family name: SCAR/WAVE
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 75 2
GENE REF ISO

Function

 show evidences
Overview 
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.  
3
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403]  
2
  • UniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • InterPro 2 GO
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Negative regulation of stress fiber assemblydefinition[GO:0051497]  
1
  • UniProtKB
Positive regulation of lamellipodium assemblydefinition[GO:0010592]  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+10163  
Bacterial invasion of epithelial cells  hsa05100+10163  
Fc gamma R-mediated phagocytosis  hsa04666+10163  
Regulation of actin cytoskeleton  hsa04810+10163  
Salmonella infection  hsa05132+10163  
Shigellosis  hsa05131+10163  
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
VEGFA-VEGFR2 Pathway  REACT_228166  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WASF2
GenomeRNAi: 10163
PRO: PR:Q9Y6W5